If you are talking about rate limiting provided by MC UI, than NO. This limit will end up in Postfix rejecting message over limit whit soft reject, so it’s MUA’s job to handle it’s queue.
On the other side as admin you can overcome this. Make MC UI limiting unlimited (or empirically decide about 2x/3x limit you usually need, maybe,..). And to ensure your next hop is not rejecting due to his rate limiting reconfigure your MC Postfix by those directives:
smtp_destination_concurrency_limit = 10
smtp_destination_rate_delay = 10s
Let’s say you submit 100 mails to gmail and 100 mail to outlook at the same time
0s: 10m -> gmail + 10m -> yahoo (180m in queue)
10s: 10m -> gmail + 10m -> yahoo (160m in queue)
Those limit can be done per destination, so let say 10 for gmail and 20 for yahoo. Or in your case just limit your next hop smart-host as you like,…