DocFraggle … Yes of course. I did whole down and up 3 times to better check if it’s working or not. Well, I experimented with Mailcow UI Theme from Lumen to materia (I like Google Material Design a lot) and the difference is here:
Default UI:

Materia UI:

so the theme change confirms that var.local.inc.php override is working perfectly fine.
If anyone want to try just go to bootswatch.com, download theme’s bootstrap.css. Rename downloaded css file as themename-bootstrap.css and copy it into data/web/css/themes/ folder.
then edit data/web/inc/vars.local.inc.php and add $UI_THEME = “materia”;
(Use your theme name instead of materia).
I haven’t tested if only restarting nginx container would bring the theme back on display so you will have to check that.