Well I would suggest to you to revert those settings to default, if you need to reduce allowed message size to 50M (half of 100M default) update only data/conf/postfix/extra.cf
, it should by enough, because you are lowering the input limit.
Why just this? (Just a guess) For example oletools mailcow default is 3145728 your 52428800 is 16x more, you may stretch this too much.
Also best bet is docker down + docker up even if docs suggest restart